What about opposing progestins? In the same way as anti-estrogen medications, anti-progestin medications can affect breast cancer? So let's say there are some anti-progestins. This has been a very politicized environment because if you think about it, just for a moment. You'll realize that a drug that blocks progestin action would be a perfect drug to induce an abortion in premenopausal women. These drugs are RU 486 and others were developed by people like the population council as a cheap contraceptive. Or as a morning-after pill, if you wish. And so they have enjoyed a very unpleasant reputation. And it's been hard to get some studies done in some cultures because of this. Anti-progestins as a treatment for breast cancer have had some mild success. They do have activities as steroid agents. They haven't been very successful, but it makes sense what you're saying. Many breast cancers are progesterone receptor-positive as well as being estrogen receptor-positive. The same could be said about drugs that target the androgen receptor. We first showed, I hate to say, nearly 50 years ago that it was easy to detect androgen receptors in breast cancer. We published that in the 1970s. And more recently, there have been some trials of anti-androgens are antigens that are non-virilizing. In women with breast cancer and particularly triple-negative breast cancer, they've been some successes there. And that's a story that's unfolding.
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